PUBMED ARTICLES

Clinical studies and cases

Influenza viruses | Dengue viruses:

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Ohter Viruses

Vaccine immunogenicity- and efficacy testing in ferrets

Humoral immune responses (ELISA, Virus Neutralization, Plaque Reduction, Haemagglutination Inhibition, etc. ) | Cell-mediated immune responses | Prime-boost strategies | Production of hyper immune serum | Longevity of protection | Dose-finding, Dose-optimization | Clinical scoring:

Antiviral efficacy and pharmaco kinetics testing in ferrets

Prophylaxis and Therapy (delayed treatment) | (Deep) sequencing, mutation-specific PCR | Any route of drug administration possible (IV, oral, nebulizer, etc.) | Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by quantitative PCR and virus titration), gross pathology, histopathology, immune histochemistry, etc. | Virus transmission:

Antiviral efficacy testing and pk analysis in non-human primates

Prophylaxis and Therapy (delayed treatment) | (Deep) sequencing, mutation-specific PCR | Any route of drug administration possible (IV, oral, nebulizer, etc.) | Read outs include: clinical scoring (signs of disease, body temperature, lung function, etc), viral loads (by quantitative PCR and virus titration), gross pathology, histopathology, immune histochemistry, etc.:

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